I haven't tried it even though I have a variflame. I just figured it wouldn't work. I read a report somewhere "possibly Hpmuzzleloading", where a PR modified BP plug was used with 6mm brass in an omega. The 6mm uses large rifle primers, using a large rifle Magnum primer for the ignition reportedly worked well. I dont know if a variflame could be machined to except large rifle primers. If it could, that might be the ticket. I've been meaning to call Cecil at PR bullet and ask him about this setup, but have not done so yet!