Never tride Lil'Gun or trail boss as these were not powders recommended to me by ANYONE. IIRC LilGun had some safety issues when used in the 10ML-II, but I might be wrong.
The two best performing powders I have tride with great success are:
RL-10X with 290 grain TMZs and 300grn Barnes "O's"
Shot both to MOA at 100yrds
And...
H-4198 with 300XTPs, 250XTPs, 245 Spitfires, 250 TMZs, 290 TMZs
This is the best OVER ALL performing powder in my 10ML-II. Shot all the above bullets at or below 1.75" MOA at 100yrds.
H-4198 was my best powder with the 245 Spitfires and XTPs shot both at or below 1.5" MOA at 100yrds. As a matter of fact H-4198 shot every bullet/sabot I tried below 2" at 100yrds.
I always recommend H-4198 as it is a great all around powder for use in the 10ML-II that USUALLY will work well with all bullet weights from 245-300 grains, will give you all the FPS you could ever want, and is most importantly, widely and easly available OTC, not the case with N110/120.
Shot N110/120 and SR4759 and N120 and SR4759 gave me 1.5" groups or better, but they could not give me the FPS I was looking for in bullets in the 290-300grn class, but shot more than accurately enough for hunting.
Hope this was helpfull.
Arthur